Article

Androgen receptor binding sites are highly mutated in prostate cancer

2017-11-27

Abstract excerpt

<h4>ABSTRACT</h4> Androgen receptor (AR) signalling is essential to nearly all prostate cancer cells. Any alterations to AR-mediated transcription can have a profound effect on prostate carcinogenesis and tumour growth. While the AR protein has been extensively studied, little is know about mutations to the non-coding regions where AR binds to DNA. Using clinical whole genome sequencing, we demonstrate that AR bi...

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Literature Corpus work: 8d1dda5f-d818-5c9a-9a94-7e5de7f51032
DOI: 10.1101/225433

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