Article
Androgen receptor-binding sites are highly mutated in prostate cancer.
Nature communications - 11 Feb 2020
Morova Tunç, McNeill Daniel R, Lallous Nada, Gönen Mehmet, Dalal Kush, Wilson David M, Gürsoy Attila, Keskin Özlem, Lack Nathan A
Abstract excerpt
Androgen receptor (AR) signalling is essential in nearly all prostate cancers. Any alterations to AR-mediated transcription can have a profound effect on carcinogenesis and tumor growth. While mutations of the AR protein have been extensively studied, little is known about those somatic mutations that occur at the non-coding regions where AR binds DNA. Using clinical whole genome sequencing, we show that AR...
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