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Article

Androgen receptor gene mutations in human prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1992

Newmark J R, Hardy D O, Tonb D C, Carter B S, Epstein J I, Isaacs W B, Brown T R, Barrack E R

Abstract excerpt

We screened human prostate cancer tissues for the presence of somatic mutations in the hormone binding domain of the androgen receptor (AR) gene. Exons E-H were amplified from genomic DNA using the polymerase chain reaction and analyzed by denaturing gradient gel electrophoresis (DGGE), which separates DNA fragments that differ by only a single base. We detected a mutation in exon E of the hormone binding domain...

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Identifiers

PMID: 1631125
DOI: 10.1073/pnas.89.14.6319
PMCID: PMC49492

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