Clinical implications of AR alterations in advanced prostate cancer: A multi-institutional collaboration

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> <italic>AR </italic>gene alterations can develop in response to pressure of testosterone suppression and androgen receptor targeting agents (ARTA). Despite this, the relevance of these gene alterations in the context of ARTA treatment and clinical outcomes remains unclear. <bold>Methods:</bold> Patients with castration-resistant prostate cancer (CRPC) who had un...

Topics

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• Androgen Antagonists
• Antineoplastic Agents, Hormonal
• Biomarkers, Tumor
• Circulating Tumor DNA
• High-Throughput Nucleotide Sequencing
• Mutation
• Prostatic Neoplasms
• Receptors, Androgen

Identifiers and source

Literature Corpus work

1ba009ea-d64b-5925-bbf9-97902d44ffb4

DOI

10.21203/rs.3.rs-3201150/v1