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Article

Extracellular matrix in bone marrow can mediate drug resistance in myeloma

1 Jun 2005

Abstract excerpt

Glucocorticoids such as dexamethasone, frequently used for the treatment of multiple myeloma (MM), produce a rapid reduction in tumor mass. However, despite frequent initial complete remission, prolonged dexamethasone treatment results in the appearance of chemoresistant tumor cells and most patients with MM ultimately present relapse of the underlying disease. Accumulating data suggest that bone marrow...

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Identifiers

PMID: 16019524
DOI: 10.1080/10428190500051448

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