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Article

Glucocorticoid Receptors and Resistance to Glucocorticoids in Hematologic Malignancies

1 Jan 1994

Abstract excerpt

Glucocorticoids are highly effective in inducing the cytolysis of cells of lymphocytic origin. This property has resulted in their incorporation into chemotherapy regimens used in the treatment of hematologic malignancies. Studies at the molecular and cellular levels have demonstrated that the hormone-induced cytolytic response is mediated through a highly specific cytoplasmic glucocorticoid receptor (GR). The GR...

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PMID: 7873993
DOI: 10.3109/10428199409049738

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