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Article

Glucocorticoid receptor transcriptional isoforms and resistance in multiple myeloma cells

1 Dec 2006

Abstract excerpt

Although glucocorticoids play an important role in the treatment of multiple myeloma, some patients do not respond or develop resistance. The glucocorticoid receptor (GR), a single gene, mediates the effects of glucocorticoids. Using a model system of a multiple myeloma cell line sensitive to glucocorticoids and its early and late resistant variants, we have analyzed mutations in the GR gene, detected the...

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PMID: 17172408
DOI: 10.1158/1535-7163.mct-06-0344

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