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Article

Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactions.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2004

Black Ben E, Vitto Michael J, Gioeli Daniel, Spencer Adam, Afshar Nima, Conaway Mark R, Weber Michael J, Paschal Bryce M

Abstract excerpt

Here we report that mutations within the DNA-binding domain of AR, shown previously to inhibit nuclear export to the cytoplasm, cause an androgen-dependent defect in intranuclear trafficking of AR. Mutation of two conserved phenylalanines within the DNA recognition helix (F582, 583A) results in androgen-dependent arrest of AR in multiple subnuclear foci. A point mutation in one of the conserved phenylalanines...

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Identifiers

PMID: 14684849
DOI: 10.1210/me.2003-0145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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