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Article

Specific properties of a C-terminal truncated androgen receptor detected in hormone refractory prostate cancer.

Advances in experimental medicine and biology - 1 Jan 2008

Lapouge Gaëlle, Marcias Gemma, Erdmann Eva, Kessler Pascal, Cruchant Marion, Serra Sebastian, Bergerat Jean-Pierre, Céraline Jocelyn

Abstract excerpt

Mutations in the human androgen receptor (AR) gene that lead to C-terminus truncated AR variants are frequently detected in prostate cancer (PC). These AR variants lack both the ligand-binding domain (LBD) and the AF-2 region. The aim of this study was to delineate the alternative mechanisms that lead to the activation of such AR variants as they are unresponsive to hormone stimulation, and to outline...

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Source

Identifiers

PMID: 18497078
DOI: 10.1007/978-0-387-69080-3_53

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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