Article

Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation

2023-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Alterations of nuclear structure and function, and associated impact on gene transcription, are a hallmark of cancer cells. Little is known of these alterations in Cancer-Associated Fibroblasts (CAFs), a key component of the tumor stroma. Here we show that loss of androgen receptor (AR), which triggers early steps of CAF activation in human dermal fibroblasts (HDFs), leads to nuclear membrane al...

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Literature Corpus work: 9bb774df-205b-57b2-b5bc-ede0abb2f0b3
DOI: 10.1101/2023.06.28.546870

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