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Article

PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function.

Biochemical and biophysical research communications - 27 Oct 2006

Greene Michael W, Ruhoff Mary S, Roth Richard A, Kim Jeong-A, Quon Michael J, Krause Jean A

Abstract excerpt

The IRS-1 PH and PTB domains are essential for insulin-stimulated IRS-1 Tyr phosphorylation and insulin signaling, while Ser/Thr phosphorylation of IRS-1 disrupts these signaling events. To investigate consensus PKC phosphorylation sites in the PH-PTB domains of human IRS-1, we changed Ser24, Ser58, and Thr191 to Ala (3A) or Glu (3E), to block or mimic phosphorylation, respectively. The 3A mutant abrogated the...

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PMID: 16970908
DOI: 10.1016/j.bbrc.2006.08.158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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