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Article

Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites.

The Journal of clinical investigation - 1 Feb 1996

Pillay T S, Xiao S, Olefsky J M

Abstract excerpt

Elevated glucose concentrations have been reported to inhibit insulin receptor kinase activity. We studied the effects of high glucose on insulin action in Rat1 fibroblasts transfected with wild-type human insulin receptor (HIRcB) and a truncated receptor lacking the COOH-terminal 43 amino acids (delta CT). In both cell lines, 25 mM glucose impaired receptor and insulin receptor substrate-1 phosphorylation by...

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Identifiers

PMID: 8609215
DOI: 10.1172/JCI118457
PMCID: PMC507096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites.PMID 8609215Read ↗

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