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Article

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta.

The Biochemical journal - 15 Feb 2004

Greene Michael W, Morrice Nick, Garofalo Robert S, Roth Richard A

Abstract excerpt

Non-esterified fatty acid (free fatty acid)-induced activation of the novel PKC (protein kinase C) isoenzymes PKCdelta and PKCtheta correlates with insulin resistance, including decreased insulin-stimulated IRS-1 (insulin receptor substrate-1) tyrosine phosphorylation and phosphoinositide 3-kinase activation, although the mechanism(s) for this resistance is not known. In the present study, we have explored the...

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Identifiers

PMID: 14583092
DOI: 10.1042/BJ20031493
PMCID: PMC1223928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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