PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes.

doi:10.1006/excr.2002.5570

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Article

PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes.

Experimental cell research - 15 Aug 2002

Lorenzo Margarita, Teruel Teresa, Hernandez Rosario, Kayali Ayse G, Webster Nicholas J G

Abstract excerpt

Based on recent studies showing that PLCgamma associates to insulin receptor, we investigated its role in insulin stimulation of glucose transport in brown adipocytes. Insulin stimulation induced rapid PLCgamma association to phosphorylated insulin receptor, and activation of PLCgamma, as assessed by the mobilization of Ca(2+) from intracellular stores and by the production of the second messenger DAG. Both...

Topics

Adipocytes
Adipose Tissue, Brown
Animals
Diglycerides
Enzyme Inhibitors
Glucose
Glucose Transporter Type 4
HL-60 Cells
Humans
Insulin
Isoenzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Monosaccharide Transport Proteins

Muscle Proteins

Mutation

Phosphatidic Acids

Phospholipase C gamma

Protein Kinase C

Rats

Source

Open in PubMed

Identifiers

PMID: 12169270
DOI: 10.1006/excr.2002.5570

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