Article
Analysis of an interferon-gamma gene dinucleotide-repeat polymorphism in Nordic multiple sclerosis patients.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jun 2001
Dai Y, Masterman T, Huang W X, Sandberg-Wollheim M, Laaksonen M, Harbo H F, Oturai A, Ryder L P, Soelberg-Sørensen P, Svejgaard A, Hillert J
Abstract excerpt
The proinflammatory cytokine interferon (IFN)-gamma has been shown to influence the course of multiple sclerosis (MS). The IFN-gamma (IFNG) contains a multiallelic dinucleotide repeat in intron 1. To investigate whether alleles at this locus influence susceptibility to MS, we performed linkage and familial association analyses on 100 sibling pairs from four Nordic countries, and case-control association analysis...
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