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Insulated hsp70B′ promoter: stringent heat‐inducible activity in replication‐deficient, but not replication‐competent adenoviruses

11 Feb 2008

Abstract excerpt

BACKGROUND: Key to the realization of gene therapy is the development of efficient and targeted gene transfer vectors. Therapeutic gene transfer by replication-deficient or more recently by conditionally replication-competent/oncolytic adenoviruses has shown much promise. For specific applications, however, it will be advantageous to provide vectors that allow for external control of gene expression. The...

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PMID: 18265421
DOI: 10.1002/jgm.1157

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