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Article

PUMA and NF-kB Are Cell Signaling Predictors of Reovirus Oncolysis of Breast Cancer

18 Jan 2017

Abstract excerpt

BACKGROUND AND PURPOSE: Reovirus is a ubiquitous RNA virus that exploits aberrant signaling pathways for its replication. The oncolytic potential of reovirus against numerous cancers under pre-clinical/clinical conditions has been documented by us and others. Despite its proven clinical activity, the underlying mechanisms of reovirus oncolysis is still not well elucidated. If reovirus therapy is to be optimized...

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PMID: 28099441
DOI: 10.1371/journal.pone.0168233

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