Article
Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model.
Cancer gene therapy - 1 Jul 2006
Day C-P, Rau K-M, Qiu L, Liu C-W, Kuo H-P, Xie X, Lopez-Berestein G, Hortobagyi G N, Hung M-C
Abstract excerpt
To ensure the success of systemic gene therapy, it is critical to enhance the tumor specificity and activity of the promoter. In the current study, we determined that topoisomerase IIalpha promoter is selectively activated in breast cancer cells. An element containing an inverted CCAAT box (ICB) was shown to be responsible for the breast cancer specificity. When the ICB-harboring topoisomerase IIalpha minimal...
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