Article
Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions.
RNA (New York, N.Y.) - 1 Jan 2004
Konevega Andrey L, Soboleva Natalia G, Makhno Valentin I, Semenkov Yuri P, Wintermeyer Wolfgang, Rodnina Marina V, Katunin Vladimir I
Abstract excerpt
The anticodon loop of tRNA contains a number of conserved or semiconserved nucleotides. In most tRNAs, a highly modified purine is found at position 37 immediately 3' to the anticodon. Here, we examined the role of the base at position 37 for tRNA(Phe) binding to the A site of Escherichia coli ribosomes. Affinities and rate constants of A-site binding of native yeast peptidyl-tRNA(Phe) with hypermodified G...
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