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Article

Functional consequences of T-stem mutations in E. coli tRNAThrUGU in vitro and in vivo.

RNA (New York, N.Y.) - 1 Jun 2011

Saks Margaret E, Sanderson Lee E, Choi Daniel S, Crosby Catherine M, Uhlenbeck Olke C

Abstract excerpt

The binding affinities between Escherichia coli EF-Tu and 34 single and double base-pair changes in the T stem of E. coli tRNA(Thr)(UGU) were compared with similar data obtained previously for several aa-tRNAs binding to Thermus thermophilus EF-Tu. With a single exception, the two proteins bound to mutations in three T-stem base pairs in a quantitatively identical manner. However, tRNA(Thr) differs from other...

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Identifiers

PMID: 21527672
DOI: 10.1261/rna.2427311
PMCID: PMC3096036

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Source receipt: pubmed, retrieved 7 Sept 2026.

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