Article
IGF-I is required for normal embryonic growth in mice.
Genes & development - 1 Dec 1993
Powell-Braxton L, Hollingshead P, Warburton C, Dowd M, Pitts-Meek S, Dalton D, Gillett N, Stewart T A
Abstract excerpt
IGF-I is a pleiotropic hormone reported to affect linear growth, glucose metabolism, organ homeostasis, and the immune and neurologic systems. In contrast to IGF-II, IGF-I is expressed at low levels embryonically and has been thought to be more important for postnatal growth and development. To i...
Topics
- Animals
- Base Sequence
- Cell Line
- Embryonic and Fetal Development
- Female
- Insulin-Like Growth Factor I
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Phenotype
- Pregnancy