Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGF-I is required for normal embryonic growth in mice.

Genes & development - 1 Dec 1993

Powell-Braxton L, Hollingshead P, Warburton C, Dowd M, Pitts-Meek S, Dalton D, Gillett N, Stewart T A

Abstract excerpt

IGF-I is a pleiotropic hormone reported to affect linear growth, glucose metabolism, organ homeostasis, and the immune and neurologic systems. In contrast to IGF-II, IGF-I is expressed at low levels embryonically and has been thought to be more important for postnatal growth and development. To investigate the role of IGF-I in normal development we generated mice with an inactive IGF-I gene by homologous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Molecular Sequence Data

Share to Phenotype

Share to Pregnancy

Source

Identifiers

PMID: 8276243
DOI: 10.1101/gad.7.12b.2609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGF-I is required for normal embryonic growth in mice.PMID 8276243Read ↗

Inactivation of the IGF-I gene in mice results in perinatal lethality.Semantic proximity Read ↗

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).Semantic proximity Read ↗

Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels.Semantic proximity Read ↗

A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit.Semantic proximity Read ↗

Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung MorphogenesisSemantic proximity Read ↗

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.Semantic proximity Read ↗

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.Semantic proximity Read ↗

Conditional Knockout of Mouse Insulin-Like Growth Factor-1 Gene Using the Cre/loxP SystemSemantic proximity Read ↗

The hormonal action of IGF1 in postnatal mouse growth.Semantic proximity Read ↗

Role of insulin-like growth factors in growth, development and feeding.Semantic proximity Read ↗

Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight.Semantic proximity Read ↗

Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.