Article
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.
Nature - 3 May 1990
DeChiara T M, Efstratiadis A, Robertson E J
Abstract excerpt
Growth factors are thought to function as pivotal autocrine-paracrine regulatory signals during embryonic development. Insulin-like growth factor II (IGF-II), a mitogenic polypeptide for a variety of cell lines, could have such a role, as indicated by the pattern of expression of its gene during...
Topics
- Animals
- Base Sequence
- Blastocyst
- Cells, Cultured
- Chimera
- Embryonic and Fetal Development
- Female
- Growth Disorders
- Heterozygote
- Insulin-Like Growth Factor II
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Pigmentation
- Polymerase Chain Reaction
- Somatomedins