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Article

Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung Morphogenesis

6 Nov 2012

Abstract excerpt

BACKGROUND: Insulin-like growth factors (IGF-I and -II) are pleiotropic regulators of somatic growth and development in vertebrate species. Endocrine and paracrine effects of both hormones are mediated by a common IGF type 1 receptor (IGF-1R). Lethal respiratory failure in neonatal IGF-1R knockout mice suggested a particular role for this receptor in pulmonary development, and we therefore investigated the...

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PMID: 23139760
DOI: 10.1371/journal.pone.0048071

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