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Article

A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin.

Journal of pediatric gastroenterology and nutrition - 1 Nov 2007

Gordon Phillip V, Herman Andrew C, Marcinkiewicz Marek, Gaston Benjamin M, Laubach Victor E, Aschner Judy L

Abstract excerpt

BACKGROUND: Early postnatal steroids and indomethacin in combination have been shown to increase the risk of spontaneous intestinal perforation (SIP) in infants with extremely low birth weight (ELBW), but the mechanism behind this synergistic effect is unknown. MATERIALS AND METHODS: Based on literature in a variety of models suggesting that glucocorticoids and nonsteroidal antiinflammatory agents diminish...

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Source

Identifiers

PMID: 18030227
DOI: 10.1097/MPG.0b013e3181558591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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