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Article

Disruption of the Igf2 gene alters hepatic lipid homeostasis and gene expression in the newborn mouse.

American journal of physiology. Endocrinology and metabolism - 1 Nov 2018

Lopez Mary Frances, Zheng Lingyun, Miao Ji, Gali Reddy, Gorski Grzegorz, Hirschhorn Joel N

Abstract excerpt

Newborns with intrauterine growth-restriction are at increased risk of mortality and life-long comorbidities. Insulin-like growth factor-II (IGF2) deficiency in humans, as well as in mice, leads to intrauterine growth restriction and decreased neonatal glycogen stores. The present study aims to further characterize the metabolic and transcriptional consequences of Igf2 deficiency in the newborn. We found that,...

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Identifiers

PMID: 30016152
DOI: 10.1152/ajpendo.00048.2018
PMCID: PMC6293172

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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