Article
Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome.
Human molecular genetics - 1 Feb 2004
Schulze Thomas G, Zhang Kui, Chen Yu-Sheng, Akula Nirmala, Sun Fengzhu, McMahon Francis J
Abstract excerpt
Recent studies suggest that the genome is organized into blocks of haplotypes, and efforts to create a genome-wide haplotype map of single-nucleotide polymorphisms (SNPs) are already underway. Haplotype blocks are defined algorithmically and to date several algorithms have been proposed. However, little is known about their relative performance in real data or about the impact of allele frequencies and parameter...
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