Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome.

doi:10.1093/hmg/ddh035

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Article

Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome.

Human molecular genetics - 1 Feb 2004

Schulze Thomas G, Zhang Kui, Chen Yu-Sheng, Akula Nirmala, Sun Fengzhu, McMahon Francis J

Abstract excerpt

Recent studies suggest that the genome is organized into blocks of haplotypes, and efforts to create a genome-wide haplotype map of single-nucleotide polymorphisms (SNPs) are already underway. Haplotype blocks are defined algorithmically and to date several algorithms have been proposed. However,...

Topics

Algorithms
Chromosome Mapping
Computational Biology
Gene Frequency
Genetic Markers
Genome, Human
Haplotypes
Humans
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

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