Article
Haplotype block partitioning and tag SNP selection using genotype data and their applications to association studies.
Genome research - 1 May 2004
Zhang Kui, Qin Zhaohui S, Liu Jun S, Chen Ting, Waterman Michael S, Sun Fengzhu
Abstract excerpt
Recent studies have revealed that linkage disequilibrium (LD) patterns vary across the human genome with some regions of high LD interspersed by regions of low LD. A small fraction of SNPs (tag SNPs) is sufficient to capture most of the haplotype structure of the human genome. In this paper, we d...
Topics
- Algorithms
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Computer Simulation
- DNA Probes
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide