Article
Efficient haplotype block partitioning and tag SNP selection algorithms under various constraints.
BioMed research international - 1 Jan 2013
Chen Wen-Pei, Hung Che-Lun, Lin Yaw-Ling
Abstract excerpt
Patterns of linkage disequilibrium plays a central role in genome-wide association studies aimed at identifying genetic variation responsible for common human diseases. These patterns in human chromosomes show a block-like structure, and regions of high linkage disequilibrium are called haplotype blocks. A small subset of SNPs, called tag SNPs, is sufficient to capture the haplotype patterns in each haplotype...
Topics
- Algorithms
- Chromosomes, Human, Pair 21
- Genetic Variation
- Genome, Human
- Genome-Wide Association Study
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Polymorphism, Single Nucleotide
- Software Design