Article
MFB-1, an F-box-type ubiquitin ligase, regulates TGF-beta signalling.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Nov 2004
Aoyama Yukako, Urushiyama Seiichi, Yamada Misato, Kato Chikako, Ide Hiroko, Higuchi Satoshi, Akiyama Tetsu, Shibuya Hiroshi
Abstract excerpt
TGF-beta signalling regulates cell growth, differentiation, morphogenesis and apoptosis. MAFbx/Atrogin-1 has been identified as a regulator for skeletal muscle atrophy and encodes an F-box-type E3 ubiquitin ligase. However, little is known about how MAFbx/Atrogin-1 regulates cellular signalling....
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