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Article

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.

Nature - 26 Mar 1992

Clark S G, Stern M J, Horvitz H R

Abstract excerpt

The induction of the hermaphrodite vulva and the migration of the sex myoblasts in the nematode Caenorhabditis elegans are both controlled by intercellular signalling. The gonadal anchor cell induces formation of the vulva from nearby hypodermal cells, and a set of somatic gonadal cells attract the migrating sex myoblasts to their final positions. Many genes required for vulval induction have been identified,...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis
Chromosome Mapping
DNA
DNA Mutational Analysis
Genes
Genes, Suppressor
Molecular Sequence Data
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoproteins

Phosphotyrosine

Signal Transduction

Tyrosine

Source

Identifiers

PMID: 1372395
DOI: 10.1038/356340a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1372395-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.PMID 1372395Read ↗

sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.Semantic proximity Read ↗

sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox.Semantic proximity Read ↗

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Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction.Semantic proximity Read ↗

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sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans.Semantic proximity Read ↗

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A cell-specific enhancer that specifieslin-3expression in theC. elegansanchor cell for vulval developmentSemantic proximity Read ↗

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