Article
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
Development (Cambridge, England) - 1 Jan 1999
Krishna S, Maduzia L L, Padgett R W
Abstract excerpt
In C. elegans, the TGFbeta-like type II receptor daf-4 is required for two distinct signaling pathways. In association with the type I receptor daf-1, it functions in the dauer pathway. In addition, it is also required for body size determination and male tail patterning, roles which do not requi...
Topics
- Activin Receptors, Type I
- Alleles
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Body Constitution
- Body Patterning
- Bone Morphogenetic Protein Receptors, Type I
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cloning, Molecular
- Gene Expression Regulation, Developmental
- Helminth Proteins
- Male
- Molecular Sequence Data
- Phenotype
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type I