Article
Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation.
Neurobiology of disease - 1 Dec 2003
Luthi-Carter Ruth, Apostol Barbara L, Dunah Anthone W, DeJohn Molly M, Farrell Laurie A, Bates Gillian P, Young Anne B, Standaert David G, Thompson Leslie M, Cha Jang Ho J
Abstract excerpt
We analyzed NMDA receptor subunit mRNAs, proteins, and anchoring proteins in mice transgenic for exon 1 of the HD gene. R6/2 mice had decreased levels of mRNAs encoding epsilon1 and epsilon2 NMDA receptor subunits (mouse orthologs of rat NR2A and NR2B subunits), but not the zeta1 subunit (mouse ortholog of NR1), as assessed by gene expression profiling and Northern blotting. In situ hybridization resolved mRNA...
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