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Article

Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome

4 Jan 2012

Abstract excerpt

The Ts65Dn mouse model of Down syndrome (DS) is trisomic for orthologs of 88 of 161 classical protein coding genes present on human chromosome 21 (HSA21). Ts65Dn mice display learning and memory impairments and neuroanatomical, electrophysiological, and cellular abnormalities that are relevant to phenotypic features seen in DS; however, little is known about the molecular perturbations underlying the...

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PMID: 22214338
DOI: 10.1021/pr2011582

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