Article
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice.
Neuron - 28 Jan 2010
Milnerwood Austen J, Gladding Clare M, Pouladi Mahmoud A, Kaufman Alexandra M, Hines Rochelle M, Boyd Jamie D, Ko Rebecca W Y, Vasuta Oana C, Graham Rona K, Hayden Michael R, Murphy Timothy H, Raymond Lynn A
Abstract excerpt
N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs are poor therapeutic targets, due to their essential physiological role. Recent studies demonstrate that synaptic NMDAR transmission drives neuroprotective gene transcription, whereas extrasynaptic NMDAR activation promotes cell death. We...
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