Article
NMDA receptor function in mouse models of Huntington disease.
Journal of neuroscience research - 15 Nov 2001
Cepeda C, Ariano M A, Calvert C R, Flores-Hernández J, Chandler S H, Leavitt B R, Hayden M R, Levine M S
Abstract excerpt
Huntington disease (HD) is an autosomal dominant disorder in which degeneration of medium-sized spiny striatal neurons occurs. The HD gene and the protein it encodes, huntingtin, have been identified but their functions remain unknown. Transgenic mouse models for HD have been developed and we examined responses of medium-sized striatal neurons recorded in vitro to application of N-methyl-D-aspartate (NMDA) in two...
Topics
- Animals
- Behavior, Animal
- Calcium Channels
- Calcium Signaling
- Disease Models, Animal
- Excitatory Amino Acid Agonists
- Excitatory Amino Acid Antagonists
- Huntington Disease
- Immunohistochemistry
- Ion Channels