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Article

NMDA receptor function in mouse models of Huntington disease.

Journal of neuroscience research - 15 Nov 2001

Cepeda C, Ariano M A, Calvert C R, Flores-Hernández J, Chandler S H, Leavitt B R, Hayden M R, Levine M S

Abstract excerpt

Huntington disease (HD) is an autosomal dominant disorder in which degeneration of medium-sized spiny striatal neurons occurs. The HD gene and the protein it encodes, huntingtin, have been identified but their functions remain unknown. Transgenic mouse models for HD have been developed and we examined responses of medium-sized striatal neurons recorded in vitro to application of N-methyl-D-aspartate (NMDA) in two...

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PMID: 11746372
DOI: 10.1002/jnr.1244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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