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Article

Distinct responses of xenografted gliomas to different alkylating agents are related to histology and genetic alterations.

Cancer research - 1 Jul 2004

Leuraud Pascal, Taillandier Luc, Medioni Jacques, Aguirre-Cruz Lucinda, Crinière Emmanuelle, Marie Yannick, Kujas Michèle, Golmard Jean-Louis, Duprez Adrien, Delattre Jean-Yves, Sanson Marc, Poupon Marie-France

Abstract excerpt

A series of 12 human gliomas was established as xenografts in nude mice and used to evaluate the relationship between histology, genetic parameters, and response to alkylating agents. Eight were high-grade oligodendroglial tumors, and four were glioblastoma. They were characterized for their genetic alterations, including those considered as "early" alterations, namely loss of chromosome 1 +/- loss of chromosome...

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15231677
DOI: 10.1158/0008-5472.CAN-03-3429

Genes

EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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