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Article

Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy.

Brain pathology (Zurich, Switzerland) - 1 Jul 2008

Claes An, Schuuring Janneke, Boots-Sprenger Sandra, Hendriks-Cornelissen Sandra, Dekkers Marieke, van der Kogel Albert J, Leenders William P, Wesseling Pieter, Jeuken Judith W

Abstract excerpt

Most human gliomas are characterized by diffuse infiltrative growth in the brain parenchyma. Partly because of this characteristic growth pattern, gliomas are notorious for their poor response to current therapies. Many animal models for human gliomas, however, do not display this diffuse infiltrative growth pattern. Furthermore, there is a need for glioma models that represent adequate genocopies of different...

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Identifiers

PMID: 18371177
DOI: 10.1111/j.1750-3639.2008.00141.x
PMCID: PMC8095630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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