Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.

Biochemistry - 1 Jul 2014

Yu Zhi-Hong, Zhang Ruo-Yu, Walls Chad D, Chen Lan, Zhang Sheng, Wu Li, Liu Sijiu, Zhang Zhong-Yin

Abstract excerpt

The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2) is a critical signal transducer downstream of growth factors that promotes the activation of the RAS-ERK1/2 cascade. In its basal state, SHP2 exists in an autoinhibited closed conformation because of an intramolecular interaction between its N-SH2 and protein tyrosine phosphatase (PTP) domains. Binding to pTyr ligands present on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to HEK293 Cells
Share to LEOPARD Syndrome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Protein Conformation

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to src Homology Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 24935154
DOI: 10.1021/bi5002695
PMCID: PMC4081049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.PMID 24935154Read ↗

Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations.Semantic proximity Read ↗

Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11).Semantic proximity Read ↗

Structure, function, and pathogenesis of SHP2 in developmental disorders and tumorigenesis.Semantic proximity Read ↗

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.Semantic proximity Read ↗

SHP2 sails from physiology to pathology.Semantic proximity Read ↗

The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domainSemantic proximity Read ↗

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation.Semantic proximity Read ↗

The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain.Semantic proximity Read ↗

Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.Semantic proximity Read ↗

Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1.Semantic proximity Read ↗

[The Biological Function of SHP2 in Human Disease].Semantic proximity Read ↗

Targeting SHP2 phosphatase in hematological malignancies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.