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Article

D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane.

FEBS letters - 1 Apr 2016

Jun Yong-Woo, Park Heeju, Lee You-Kyung, Kaang Bong-Kiun, Lee Jin-A, Jang Deok-Jin

Abstract excerpt

Dual A-kinase anchoring protein 1a (D-AKAP1a, AKAP1) regulates cAMP signaling in mitochondria. However, it is not clear how D-AKAP1a is associated with mitochondria. In this study, we show that D-AKAP1a is a transmembrane protein in the mitochondrial outer membrane (MOM). We revealed that the N-terminus of D-AKAP1a is exposed to the intermembrane space of mitochondria and that its C-terminus is located on the...

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Identifiers

PMID: 26950402
DOI: 10.1002/1873-3468.12123

Genes

AKAP1

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