Article
Mutagenesis of a single AT basepair in mice transgenic for PhiX174 am3, cs70. II. Brain.
Mutation research - 21 Jul 1999
Malling H V, Newbold R R, Lewis S, Barnett L, Weaver R P
Abstract excerpt
Most cell divisions in the mouse brain have ceased by 14 days after birth. Therefore, spontaneous mutations that occur in brain cells can be assumed to be fixed by replication during brain development. Spontaneous and ethylnitrosourea (ENU)-induced reverse mutations at a single AT base pair were measured in brain tissue by using mice transgenic for PhiX174 am3, cs70. The line (am54) has 50 PhiX genomes per...
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