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Article

A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway.

Journal of virology - 1 Jan 2004

Querbes W, Benmerah A, Tosoni D, Di Fiore P P, Atwood Walter J

Abstract excerpt

Infectious entry of JC virus (JCV) into human glial cells occurs by receptor-mediated clathrin-dependent endocytosis. In this report we demonstrate that the tyrosine kinase inhibitor genistein blocks virus entry and inhibits infection. Transient expression of dominant-negative eps15 mutants, including a phosphorylation-defective mutant, inhibited both virus entry and infection. We also show that the JCV-induced...

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Source

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Identifiers

PMID: 14671106
DOI: 10.1128/jvi.78.1.250-256.2004
PMCID: PMC303400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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