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JC Virus Enters Human Glial Cells by Clathrin-Dependent Receptor-Mediated Endocytosis

1 Mar 2000

Abstract excerpt

The human polyomavirus JC virus (JCV) is the etiologic agent of a fatal central nervous system (CNS) demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs predominantly in immunosuppressed patients and has increased dramatically as a result of the AIDS pandemic. The major target cell of JCV infection and lytic replication in the CNS is the oligodendrocyte. The mechanisms by...

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PMID: 10666259
DOI: 10.1128/jvi.74.5.2288-2292.2000

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