Article
Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry.
Journal of virology - 1 Feb 2005
Daecke Jessica, Fackler Oliver T, Dittmar Matthias T, Kräusslich Hans-Georg
Abstract excerpt
Productive entry of human immunodeficiency virus (HIV) is believed to occur by direct fusion at the plasma membrane. Endocytic uptake of HIV particles has been observed in several studies but is considered to be nonproductive, leading to virus degradation in the lysosome. We show here that endocytosis contributes significantly to productive HIV entry in HeLa cells by using trans dominant-negative mutants of...
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