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Orthobunyavirus Entry into Neurons and Other Mammalian Cells Occurs via Clathrin-Mediated Endocytosis and Requires Trafficking into Early Endosomes

24 May 2012

Abstract excerpt

La Crosse virus (LACV) is a leading cause of pediatric encephalitis and aseptic meningitis in the midwestern and southern United States, where it is considered an emerging human pathogen. No specific therapies or vaccines are available for LACV or any other orthobunyaviruses. Inhibition of LACV entry into cells is a potential target for therapeutic intervention, but this approach is limited by our current...

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Mosquito-borne diseases and control
Vector-Borne Animal Diseases
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22623766
DOI: 10.1128/jvi.00140-12

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