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Article

Invasion of host cells by JC virus identifies a novel role for caveolae in endosomal sorting of noncaveolar ligands.

Journal of virology - 1 Oct 2006

Querbes W, O'Hara B A, Williams G, Atwood W J

Abstract excerpt

Invasion of glial cells by the human polyomavirus, JC virus (JCV), leads to a rapidly progressing and uniformly fatal demyelinating disease known as progressive multifocal leukoencephalopathy. The endocytic trafficking steps used by JCV to invade cells and initiate infection are not known. We demonstrated that JCV infection was inhibited by dominant defective and constitutively active Rab5-GTPase mutants that...

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Identifiers

PMID: 16973546
DOI: 10.1128/JVI.01086-06
PMCID: PMC1617268

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Invasion of host cells by JC virus identifies a novel role for caveolae in endosomal sorting of noncaveolar ligands.PMID 16973546Read ↗

JC Polyomavirus Entry by Clathrin-Mediated Endocytosis Is Driven by β-ArrestinSemantic proximity Read ↗

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Orthobunyavirus Entry into Neurons and Other Mammalian Cells Occurs via Clathrin-Mediated Endocytosis and Requires Trafficking into Early EndosomesSemantic proximity Read ↗

The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entrySemantic proximity Read ↗

Traffic of JC Virus from Sites of Initial Infection to the Brain: The Path to Progressive Multifocal LeukoencephalopathySemantic proximity Read ↗

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