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Article

Is the "K-type" caffeine-halothane responder susceptible to malignant hyperthermia?

British journal of anaesthesia - 1 Nov 1992

Ellis F R, Halsall P J, Hopkins P M

Abstract excerpt

The "K-type" designation is used to describe a patient being investigated for malignant hyperthermia (MH) when concurrent administration of caffeine and halothane induces muscle contracture (rigidity, spasm) in vitro, but when halothane and caffeine given separately produce a normal response. It is accepted in some centres that K-type individuals are susceptible to malignant hyperthermia (MHS). In this paper, the...

Topics

Caffeine
Culture Techniques
Disease Susceptibility
Halothane
Humans
Malignant Hyperthermia
Muscle Contraction
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1467078
DOI: 10.1093/bja/69.5.468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1467078-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Is the "K-type" caffeine-halothane responder susceptible to malignant hyperthermia?PMID 1467078Read ↗

[Modern diagnostic approaches to malignant hyperthermia susceptibility].Semantic proximity Read ↗

Similar susceptibility to halothane, caffeine and ryanodine in vitro reflects pharmacogenetic variability of malignant hyperthermia.Semantic proximity Read ↗

Phenotyping malignant hyperthermia susceptibility by measuring halothane-induced changes in myoplasmic calcium concentration in cultured human skeletal muscle cells.Semantic proximity Read ↗

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Pathological findings in 165 patients explored for malignant hyperthermia susceptibility.Semantic proximity Read ↗

Malignant hyperthermia susceptibility, an autosomal dominant disorder?Semantic proximity Read ↗

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