Article
Similar susceptibility to halothane, caffeine and ryanodine in vitro reflects pharmacogenetic variability of malignant hyperthermia.
European journal of anaesthesiology - 1 Feb 2004
Ginz H F, Girard T, Censier K, Urwyler A
Abstract excerpt
BACKGROUND AND OBJECTIVE: To analyse the use of standardized application of ryanodine for in vitro muscle contracture testing to define cut-off values separating malignant hyperthermia susceptible from malignant hyperthermia negative subjects. Furthermore, we compared the results of in vitro muscle-contracture tests following the halothane, caffeine and ryanodine challenges. METHODS: In 113 subjects, halothane,...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anesthetics, Inhalation
- Biopsy
- Caffeine
- Central Nervous System Stimulants
- Dose-Response Relationship, Drug
- Female
- Genetic Predisposition to Disease
- Halothane
- Humans
- In Vitro Techniques