Article
Atypical reactions to halothane in a subgroup of homozygous malignant hyperthermia(MH)-susceptible pigs: indication of a heterogenous genetic basis for the porcine syndrome.
DTW. Deutsche tierarztliche Wochenschrift - 1 Oct 1992
Richter A, Gerdes C, Löscher W
Abstract excerpt
Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle. In genetically susceptible pigs, MH can be induced by volatile, halogenated anaesthetics such as halothane. Within a series of pharmacological investigations, a fulminant MH could be induced in 59 of 66 homozygous halothane-susceptible pigs by a challenge with 3% halothane for 15 minutes. The typical MH was characterized by sudden...
Topics
- Animals
- Female
- Genetic Predisposition to Disease
- Halothane
- Homozygote
- Male
- Malignant Hyperthermia
- Swine
- Swine Diseases