Xenon does not induce contracture in human malignant hyperthermia muscle.

doi:10.1093/bja/85.5.712

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Article

Xenon does not induce contracture in human malignant hyperthermia muscle.

British journal of anaesthesia - 1 Nov 2000

Baur C P, Klingler W, Jurkat-Rott K, Froeba G, Schoch E, Marx T, Georgieff M, Lehmann-Horn F

Abstract excerpt

Xenon has many characteristics of an ideal anaesthetic agent. It is not known whether xenon is a safe alternative to the potent inhalational anaesthetics in patients susceptible to malignant hyperthermia (MH). We investigated the effect of xenon, halothane and caffeine on muscle specimens of 31 individuals, referred to the MH Unit of the University of Ulm, and performed genetic epidemiology. Thirteen individuals...

Topics

Anesthetics, Inhalation
Caffeine
Culture Techniques
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Genetic Predisposition to Disease
Halothane
Humans
Malignant Hyperthermia
Muscle Contraction
Muscle, Skeletal
Phosphodiesterase Inhibitors
Xenon

Source

Open in PubMed

Identifiers

PMID: 11094586
DOI: 10.1093/bja/85.5.712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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