Article
Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer.
Cancer letters - 8 Jan 2004
Haddad Riad, Vincent John B, Gryfe Robert, Kim Hyeja, Wen Joseph, Redston Mark, Scherer Stephen W, Gallinger Steven
Abstract excerpt
ST7 is a putative tumor suppressor gene on chromosome 7q31. However, the role of ST7 as a tumor suppressor is uncertain as somatic mutations have been difficult to demonstrate. In order to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31. The entire RAY1/ST7 gene, including intron/exon boundaries and alternate 5'...
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